UNC-1215
UNC-1215 Basic information
- Product Name:
- UNC-1215
- Synonyms:
-
- UNC 1215; UNC1215
- CS-714
- N-Phenyl-2,5-bis({[4-(pyrrolidin-1-yl)piperidin-1-yl]carbonyl})aniline
- UNC 1215
- UNC1215
- UNC-1215
- (2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone)
- 1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]
- CAS:
- 1415800-43-9
- MF:
- C32H43N5O2
- MW:
- 529.72
- Product Categories:
-
- Inhibitors
- Mol File:
- 1415800-43-9.mol
UNC-1215 Chemical Properties
- Boiling point:
- 712.1±60.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear
- pka
- 9.90±0.20(Predicted)
- form
- powder
- color
- white to beige
UNC-1215 Usage And Synthesis
Uses
UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containing peptides
Definition
ChEBI: [3-anilino-4-[oxo-[4-(1-pyrrolidinyl)-1-piperidinyl]methyl]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a member of benzamides and a N-acylpiperidine.
Biological Activity
UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins th at are important epigenetic regulators th at “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions th at regulate gene expression. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. For full characterization details, please visit the UNC1215 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
target
L3MBTL3
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