5-METHOXYPICOLINALDEHYDE Chemical Properties

Boiling point:

248.4±20.0 °C(Predicted)

Density 

1.159±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.16±0.10(Predicted)

form 

solid

color 

White to off-white

InChI

InChI=1S/C7H7NO2/c1-10-7-3-2-6(5-9)8-4-7/h2-5H,1H3

InChIKey

CTYUCLSCBVSTAA-UHFFFAOYSA-N

SMILES

C1(C=O)=NC=C(OC)C=C1

Safety Information

HS Code 

2933399990

5-METHOXYPICOLINALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-methoxypyridine-2-aldehyde from 5-fluoropyridine-2-aldehyde and sodium methanol: 5-fluoropyridine-2-aldehyde (450 mg, 3.60 mmol) and sodium methanol (291 mg, 5.40 mmol) were dissolved in methanol (15 mL), and the reaction was stirred at 55 °C overnight. After completion of the reaction, the reaction mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by ISCO medium pressure liquid chromatography (MPLC) system using 30-45% ethyl acetate/hexane as eluent to afford 5-methoxypyridin-2-aldehyde as colorless oil (326 mg, 66.1% yield).1H NMR (CDCl3) δ 9.93 (s, 1H), 8.37 (d, 1H), 7.90 (d, 1H), 7.24 (d, 1H), 7.24 (d, 1H), 7.30 (d, 1H). 1H), 7.24 (dd, 1H), 3.89 (s, 3H).

References

[1] Patent: WO2009/27746, 2009, A1. Location in patent: Page/Page column 111

5-METHOXYPICOLINALDEHYDE(22187-96-8)Related Product Information

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