POMALIDOMIDE-C9-CO2H Chemical Properties

Boiling point:

714.1±55.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

powder or crystals

pka

4.78±0.10(Predicted)

POMALIDOMIDE-C9-CO2H Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-C₉-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-C9-CO2H(2243000-24-8)Related Product Information

• E3 ligase Ligand-Linker Conjugates 49
• 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
• E3 ligase Ligand-Linker Conjugates 55
• 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
• Pomalidomide-6-2-2-6-N3
• Pomalidomide-amido-C1-Br
• Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
• Pomalidomide-C6-PEG3-butyl iodide
• 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• Pomalidomide-C3-NH2
• Pomalidomide-C6-NH2?hydrochloride
• Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-