POMALIDOMIDE-C9-CO2H Chemical Properties

Boiling point:

714.1±55.0 °C(Predicted)

Density 

1.326±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

powder or crystals

pka

4.78±0.10(Predicted)

InChI

1S/C23H29N3O6/c27-18-13-12-17(21(30)25-18)26-22(31)15-9-8-10-16(20(15)23(26)32)24-14-7-5-3-1-2-4-6-11-19(28)29/h8-10,17,24H,1-7,11-14H2,(H,28,29)(H,25,27,30)

InChIKey

BGTVAMUEPLYYJY-UHFFFAOYSA-N

SMILES

OC(CCCCCCCCCNC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

POMALIDOMIDE-C9-CO2H Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-C₉-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

POMALIDOMIDE-C9-CO2H(2243000-24-8)Related Product Information

• E3 ligase Ligand-Linker Conjugates 49
• E3 ligase Ligand-Linker Conjugates 55
• 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
• Pomalidomide-6-2-2-6-N3
• Pomalidomide-amido-C1-Br
• Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
• Pomalidomide-C6-PEG3-butyl iodide
• 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
• Pomalidomide-C3-NH2
• Pomalidomide-C6-NH2?hydrochloride
• Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
• Pomalidomide 4'-alkylC5-acid
• Thalidomide-NH-PEG2-C2-NH2 (TFA)
• 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,