E3 ligase Ligand-Linker Conjugates 49
E3 ligase Ligand-Linker Conjugates 49 Basic information
- Product Name:
- E3 ligase Ligand-Linker Conjugates 49
- Synonyms:
-
- Cereblon Ligand-Linker Conjugates 14
- E3 ligase Ligand-Linker Conjugates 49
- Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
- 3,9,12,18-Tetraoxaeicosanoic acid, 20-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]amino]-20-oxo-
- 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,12,15,21-tetraoxa-3-azatricosan-23-oic acid
- 1-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]-2,8,11,17-tetraoxanonadecan-19-oic acid
- 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-4-oxo-6,12,15,21-tetraoxa-3-azatricosan-23-oic acid?, Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
- 20-[[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]amino]-20-oxo-3,9,12,18-tetraoxaeicosanoic acid
- CAS:
- 2351103-63-2
- MF:
- C31H44N4O11
- MW:
- 648.7
- Mol File:
- 2351103-63-2.mol
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E3 ligase Ligand-Linker Conjugates 49 Chemical Properties
- Boiling point:
- 900.2±65.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 3.52±0.10(Predicted)
- form
- Oil
- color
- Light brown to brown
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E3 ligase Ligand-Linker Conjugates 49 Usage And Synthesis
Uses
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
IC 50
Cereblon
References
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
E3 ligase Ligand-Linker Conjugates 49Supplier
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E3 ligase Ligand-Linker Conjugates 49(2351103-63-2)Related Product Information
- Pomalidomide 4'-alkylC5-acid
- Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
- Pomalidomide-C6-PEG3-butyl iodide
- POMALIDOMIDE-C9-CO2H
- Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
- E3 ligase Ligand-Linker Conjugates 55
- 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
- Pomalidomide-6-2-2-6-N3
- Pomalidomide-amido-C1-Br
- Pomalidomide-C6-NH2?hydrochloride
- Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-