t-Boc-Aminooxy-PEG7-amine CAS#: 2226611-29-4

t-Boc-Aminooxy-PEG7-amine Basic information

Product Name:

t-Boc-Aminooxy-PEG7-amine

Synonyms:

t-Boc-Aminooxy-PEG7-amine
3,6,9,12,15,18,21,24-Octaoxa-2-azahexacosanoic acid, 26-amino-, 1,1-dimethylethyl ester
BocHNO-PEG7-CH2CH2NH2
Boc-NHO-PEG7-CH2CH2NH2

CAS:

2226611-29-4

MF:

C21H44N2O10

MW:

484.58

Mol File:

2226611-29-4.mol

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t-Boc-Aminooxy-PEG7-amine Chemical Properties

Density: 1.096±0.06 g/cm3(Predicted)
pka: 8.74±0.10(Predicted)

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t-Boc-Aminooxy-PEG7-amine Usage And Synthesis

Description

t-Boc-Aminooxy-PEG7-amine is an aqueous soluble reagent with a Boc-protected aminooxy group and an amino group. The amino group is reactive with carboxylic acids, activated NHS esters. The protected aminooxy can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage.

Uses

t-Boc-Aminooxy-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-Aminooxy-PEG7-amineSupplier

Amatek Scientific Co. Ltd.

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TargetMol Chemicals Inc.

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