Boc-Aminooxy-PEG3-acid CAS#: 1835759-82-4

Boc-Aminooxy-PEG3-acid Basic information

Product Name:

Boc-Aminooxy-PEG3-acid

Synonyms:

Boc-Aminooxy-PEG3-acid
t-Boc-Aminooxy-PEG3-acid
N-Boc-Aminooxy-PEG3-acid
3,6,9,12-Tetraoxa-2-azapentadecanedioic acid, 1-(1,1-dimethylethyl) ester
1-{[(tert-butoxy)carbonyl]amino}-1,4,7,10-tetraoxatridecan-13-oic acid
t-Boc-Aminooxy-PEG3-acid t-Boc-
BocHNO-PEG3-CH2CH2COOH
2,2-Dimethyl-4-oxo-3,6,9,12,15-pentaoxa-5-azaoctadecan-18-oic acid

CAS:

1835759-82-4

MF:

C14H27NO8

MW:

337.37

Mol File:

1835759-82-4.mol

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Boc-Aminooxy-PEG3-acid Chemical Properties

Density: 1.155±0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DMF, DCM
pka: 4.28±0.10(Predicted)

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Boc-Aminooxy-PEG3-acid Usage And Synthesis

Description

t-Boc-Aminooxy-PEG3-acid is a PEG linker containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions.

Uses

Boc-Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Boc-Aminooxy-PEG3-acidSupplier

Bide Pharmatech Ltd.

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Email: product02@bidepharm.com

Jinan elephant international trading co., LTD

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Email: 13006575422@163.com

Amatek Scientific Co. Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Email: sales@alphabiopharm.com

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