Aminoxy-PEG3-acid Chemical Properties

Boiling point:

415.9±40.0 °C(Predicted)

Density 

1.181±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

form 

Oil

color 

Colorless to light yellow

Aminoxy-PEG3-acid Usage And Synthesis

Description

Aminooxy-PEG3-acid HCl salt is a PEG linker containing an aminooxy group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Aminoxy-PEG3-acid(1807540-79-9)Related Product Information

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• Aminooxy-PEG2-alcohol
• Aminooxy-PEG4-alcohol
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• Aminooxy-PEG3-t-butyl ester