Aminooxy-PEG4-azide Usage And Synthesis

Description

Aminooxy-PEG4-azide is a heterobifunctional crosslinker containing an aminooxy group and an azide group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Aminooxy-PEG4-azide(2100306-61-2)Related Product Information

• Aminoxy-PEG4-acid
• Aminooxy-PEG3-t-butyl ester
• Aminoxy-PEG3-acid
• Azido-PEG3-Maleimide
• Aminooxy-PEG2-azide
• Bromo-PEG3-azide
• Bromoacetamido-PEG4-azido
• 1-isothiocyanato-PEG3-Azide
• Azido-PEG5-acid
• MPEG8-N3
• -
• Aminoxy-PEG3-azide
• PEG-Azide, O-(2-Azidoethyl)-Oμ-methylpolyethylene glycol
• Azido-PEG7-acid
• Bromo-PEG4-Azide
• N3-PEG8-CH2CH2COOH
• Aminooxy-PEG4-t-butyl ester
• Aminooxy-PEG5-NH-Boc