Aminooxy-PEG2-azide
Aminooxy-PEG2-azide Basic information
- Product Name:
- Aminooxy-PEG2-azide
- Synonyms:
-
- Aminooxy-PEG2-azide
- CAS:
- 1043426-13-6
- MF:
- C6H14N4O3
- MW:
- 190.2
- Mol File:
- 1043426-13-6.mol
Aminooxy-PEG2-azide Chemical Properties
- solubility
- Soluble in Water, DMSO, DMF, DCM
Aminooxy-PEG2-azide Usage And Synthesis
Description
Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Biological Activity
Aminooxy-PEG2-azide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.It is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Non-cleavable
|
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