(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE Chemical Properties

Boiling point:

425.3±40.0 °C(Predicted)

Density 

1.390±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

0.1 M NaOH: 15 mg/mL

form 

solid

pka

1.76±0.10(Predicted)

color 

White to off-white

optical activity

[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29224985

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE Usage And Synthesis

Chemical Properties

white to off-white solid

Uses

Active enantiomer of (±)-MCPG

Definition

ChEBI: (S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. It has a role as a metabotropic glutamate receptor antagonist.

Biological Activity

Active isomer of (RS)-MCPG ((RS)-a-Methyl-4-carboxyphenylglycine ). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™ , Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

Biochem/physiol Actions

(+)-α-Methyl-4-carboxyphenylglycine, also known as MCPG, is a competitive metabotropic glutamate receptor antagonist.

storage

Room temperature

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE(150145-89-4)Related Product Information

• (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
• 4-(2-hydroxyethyl)benzoic acid
• 2-AMINO-2-PHENYLPROPIONIC ACID
• (S)-(-)-1-(P-TOLYL)ETHYLAMINE
• 1-(4-METHYLPHENYL)ETHYLAMINE 96
• 2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID
• 4-CARBOXYPHENYLACETIC ACID
• (R)-(+)-1-(4-Methoxyphenyl)ethylamine
• 4-(HYDROXYMETHYL)PHENYLACETIC ACID
• Benzenemethanol, 4-[(1R)-1-aminoethyl]-
• 4-(1-AMINO-ETHYL)-BENZOIC ACID
• (RS)-4-CARBOXYPHENYLGLYCINE
• (2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID
• 1-(4-METHYLPHENYL)-1-METHYLETHYLAMINE
• (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
• (S)-4-(1-AMINOETHYL)BENZOIC ACID
• (S)-4-CARBOXYPHENYLGLYCINE
• (2S)-2-AMINO-2-PHENYLPROPANOIC ACID