(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27) CAS#: 201995-58-6

(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27) Basic information

Product Name:

(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27)

Synonyms:

(Lys1?,Arg1?,Leu2?)-VIP (1-7)-GRF (8-27)
L-Leucinamide, L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-lysyl-L-arginyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-
(Lys??,Arg??,Leu??)-VIP (1-7)-GRF (8-27) trifluoroacetate salt
K15,R16,L27]VIP(1-7)/GRF(8-27)(acetate)

CAS:

201995-58-6

MF:

C142H240N44O38

MW:

3171.75

Mol File:

201995-58-6.mol

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(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27) Chemical Properties

Density: 1.44±0.1 g/cm3(Predicted)
form: Solid
color: White to off-white
Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Lys-Arg-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-NH2

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(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27) Usage And Synthesis

Uses

[K15,R16,L27]VIP(1-7)/GRF(8-27), a VIP1 selective agonist, exhibits IC50 values of binding of 2 nM, 1 nM, 30,000 nM for the human VIP1, rat VIP1, rat VIP2 receptors, respectively[1]. VIP: VASOACTIVE Intestinal Polypeptide

References

[1] P Gourlet, et al. Development of high affinity selective VIP1 receptor agonists. Peptides. 1997;18(10):1539-45. DOI:10.1016/s0196-9781(97)00228-3

(Lys1,Arg1,Leu2)-VIP (1-7)-GRF (8-27)Supplier

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