Ethyl N-(4-methylphenyl)sulfonylcarbamate Chemical Properties

Melting point:

82-84oC

Boiling point:

272℃ at 100.8-101kPa

Density 

1.38 at 20℃

vapor pressure 

1.8-7.9Pa at 20-25℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

color 

White

LogP

0.73-1.7 at 23℃ and pH2-7

Surface tension

63.8mN/m at 1g/L and 20℃

Ethyl N-(4-methylphenyl)sulfonylcarbamate Usage And Synthesis

Uses

Tosylurethane (Gliclazide EP Impurity C) is an intermediate in the synthesis of Gliclazide (G409877), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.

Synthesis

GENERAL STEPS: Dissolve 4-methylphenylsulfonylcarbamate (Compound, CAS:31224-37-0) in selected alcohol (ethanol, 2 mL) in a microwaveable reaction vial. The reaction vial was sealed using an aluminum cap with a PTFE-faced septum. The reaction mixture was placed in a microwave reactor and radiantly heated at 100-120°C for 20-60 min. Upon completion of the reaction, the crude product was concentrated under reduced pressure and the residue was subsequently purified by silica gel column chromatography to finally obtain the target product, ethyl N-(4-methylphenyl)sulfonylcarbamate.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 13, p. 1476 - 1478

Ethyl N-(4-methylphenyl)sulfonylcarbamate(5577-13-9)Related Product Information

• Trinexapac-ethyl
• Ethyl imidazole-4-carboxylate
• Ethyl acetate
• Ethanol
• Urethane
• Ethylparaben
• Ethyl acrylate
• Ethyl propiolate
• Benzocaine
• Ethyl cyanoacetate
• Chlorpropham
• ISOXADIFEN-ETHYL
• N-Des(5-Methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide
• GLIMEPIRIDE RELATED COMPOUND C (20 MG) (GLIMEPIRIDE URETHANE)
• GliMepiride EP IMpurity F
• N-Des(cyclohexylaMinocarbonyl) Glipizide
• 5-DesMethyl-6-Methyl Glipizide
• ortho-GliMepiride IMpurity