RICTOR antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals. mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor. The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro. This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes. This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR.

References

[1] Sarbassov, D.D. et al. (2004) Curr. Biol. 14, 1296-1302.
[2] Sarbassov, D.D. et al. (2005) Science 307, 1098-1101.
[3] Hresko, R.C. and Mueckler, M. (2005) J. Biol. Chem. 280, 40406-40416.
[4] Ali, S.M. and Sabatini, D.M. (2005) J. Biol. Chem. 280, 19445-19448.

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