5,6-DEHYDROARACHIDONIC ACID Chemical Properties

Flash point:

17 °C

storage temp. 

−20°C

solubility 

0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid); DMF: >100 mg/ml (from Oleic Acid); DMSO: >100 mg/ml (from Oleic Acid); Ethanol: >100 mg/ml (from Oleic Acid); PBS pH 7.2: <100 μg/ml (from Oleic Acid)

form 

ethanol solution

Safety Information

Hazard Codes 

F

Risk Statements 

11-16

Safety Statements 

16-7

RIDADR 

UN 1170 3/PG 2

WGK Germany 

1

MSDS

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5,6-DEHYDROARACHIDONIC ACID Usage And Synthesis

Uses

5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation[1][2][3].

Definition

ChEBI: 5,6-dehydro Arachidonic Acid is a long-chain fatty acid.

Biological Activity

Inhibits 5-lipoxygenase of guinea pig leukocytes with an IC50 of 10 μM. In extracts of r at basophilic leukemia cells preincubated with 5,6-dehydro AA, the Ki for the conversion of arachidonic acid to 5-HPETE is 15 μM.

References

[1] Sok DE, et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun. 1982 Jul 16;107(1):101-8. DOI:10.1016/0006-291x(82)91675-8
[2] Dethlefsen SM, et al. Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth. Exp Cell Res. 1994 Jun;212(2):262-73. DOI:10.1006/excr.1994.1142
[3] Corey E J, et al. Synthesis of three potential inhibitors of the biosynthesis of leukotrienes A–E[J]. Tetrahedron Letters, 1980, 21(44): 4243-4246.

5,6-DEHYDROARACHIDONIC ACID(58688-54-3)Related Product Information

• 5-HEXYN-1-OL
• 1-HEXEN-4-YNE
• 1-PENTEN-4-YNE
• 1-OCTEN-4-YNE
• 5-HEXYNOIC ACID
• 1-NONEN-4-YNE
• 1-HEPTEN-4-YNE
• 5,6-DEHYDROARACHIDONIC ACID