5-Chloro-1H-indazole-3-carboxylic acid Chemical Properties

Melting point:

337 °C

Boiling point:

472.1±25.0 °C(Predicted)

Density 

1.644±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

solid

pka

2.82±0.30(Predicted)

color 

Yellow

Safety Information

Risk Statements 

22-36

Safety Statements 

26

HS Code 

29339900

5-Chloro-1H-indazole-3-carboxylic acid Usage And Synthesis

Application

5-Chloro-1H-indazole-3-carboxylic acid is an important pharmaceutical intermediate used to construct the core of active drug molecules.

Chemical Properties

Light yellow solid

Synthesis

1H-indazole-3-carboxylic acid was dissolved in anhydrous acetic acid in a three-necked flask, heated and stirred. After the substrate was dissolved and clarified, phosphorus oxychloride was dissolved in anhydrous acetic acid and slowly added dropwise. In an oil bath at 90°C, the mixture was condensed back into the chemical book and reacted for 14 hours. After the reaction was complete, a white precipitate was produced. It was cooled in an ice bath, vacuum filtered, and the solid was washed with ethyl acetate first and then with ether to obtain 5-Chloro-1H-indazole-3-carboxylic acid.

References

[1] Patent: WO2005/14554, 2005, A1. Location in patent: Page/Page column 60-61
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0356
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6259 - 6272
[4] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 97

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