3-CHLORO-5-NITRO-1H-INDAZOLE Chemical Properties

Melting point:

218-220

Boiling point:

415.2±25.0 °C(Predicted)

Density 

1.661±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

9?+-.0.40(Predicted)

Appearance

Yellow to brown Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

29339900

3-CHLORO-5-NITRO-1H-INDAZOLE Usage And Synthesis

Chemical Properties

Yellow solid

Synthesis

Example 112A Synthesis of 3-chloro-5-nitro-1H-indazole: Sodium hydroxide (5.00 g, 125 mmol) was dissolved in water (150 mL), 5-nitroindazole (5.00 g, 30.7 mmol) was added, and the mixture was heated until a red solution formed. The reaction mixture was cooled in an ice water bath for 15 minutes, followed by the slow addition of sodium hypochlorite solution (60.0 mL, 5.25%, 45.0 mmol). The reaction mixture was stirred at 0 °C for 5 h. After completion of the reaction, the pH was adjusted with dilute hydrochloric acid to 7. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed with water and concentrated under reduced pressure. The residue was purified by fast column chromatography to afford the target compound 3-chloro-5-nitro-1H-indazole (5.5 g, 92% yield). The product was identified by 1H NMR (300 MHz, DMSO-d6): δ 7.78 (m, 1H), 8.28 (m, 1H), 8.61 (m, 1H); mass spectrum (DCI/NH3) showed m/z 197 [M + H]+.

References

[1] Patent: US2005/137243, 2005, A1. Location in patent: Page/Page column 47
[2] Patent: US2005/277638, 2005, A1. Location in patent: Page/Page column 48
[3] European Journal of Medicinal Chemistry, 1983, vol. 18, # 5, p. 469 - 470
[4] Journal of Chemical Research, Miniprint, 1990, # 11, p. 2601 - 2615
[5] European Journal of Medicinal Chemistry, 1986, vol. 21, # 4, p. 359 - 362

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