3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE Chemical Properties

Melting point:

142-144 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

sol H2O, MeOH, EtOH; slightly sol cold MeCN; insol ether, pentane

form 

Crystalline Powder

color 

White

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

BRN 

3788921

InChI

InChI=1S/C13H16NOS.ClH/c1-11-13(7-8-15)16-10-14(11)9-12-5-3-2-4-6-12;/h2-6,10,15H,7-9H2,1H3;1H/q+1;/p-1

InChIKey

IWSVLBKHBJGMAA-UHFFFAOYSA-M

SMILES

[N+]1(=CSC(CCO)=C1C)CC1=CC=CC=C1.[Cl-]

CAS DataBase Reference

4568-71-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29341000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE Usage And Synthesis

Uses

3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, aliphatic aldehydes undergo the acyloin condensation in the presence of this catalyst and mild base. It acts as a catalyst for the addition of aliphatic and heterocyclic aldehydes to α,β-unsaturated ketones, nitriles and esters.

Synthesis

Methyl hydroxyethyl thiazole (2.86 kg), acetonitrile (8.58 kg) and benzyl chloride (2.54 kg) were mixed in a 20 L reactor fitted with a stirrer and heated to reflux for 6.5 hours. After completion of the reaction, the reaction solution was cooled to room temperature and a solid was precipitated. Acetonitrile (3 kg) was added to the reaction solution, stirred and filtered. The resulting solid was washed with acetonitrile (2.0 kg) and then dried under reduced pressure to finally obtain 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazole chloride (2.36 kg, 44% yield).

Purification Methods

Purify the chloride by recrystallisation from EtOH or H2O. If placed in a bath at 125o and heated at 2o/minute, the melting point is 140.5-141.4o. [Livermore & Sealock J Biol Chem 167 699 1947, Maier & Metzler J Am Chem Soc 79 4386 1957, Beilstein 27 III/IV 1758.]

References

[1] Patent: JP5814080, 2015, B2. Location in patent: Paragraph 0062

3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE(4568-71-2)Related Product Information

• 2,2'-Dithiobis(benzothiazole)
• Lithium chloride
• Lithium
• 4,5-Dimethylthiazole
• 3-BENZYL-4-METHYLTHIAZOLIUM CHLORIDE
• 5-Methylthiazole
• 5-(2-Hydroxyethyl)-4-methylthiazole
• 5-ethyl-4-methylthiazole
• 3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE