4,5-Dimethylthiazole Chemical Properties

Melting point:

83-84 C

Boiling point:

158 °C/742 mmHg (lit.)

Density 

1.07 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.521(lit.)

FEMA 

3274 | 4,5-DIMETHYLTHIAZOLE

Flash point:

124 °F

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

pK1:3.73 (25°C,μ=0.1)

Specific Gravity

1.070

Odor

at 0.10 % in dipropylene glycol. roasted nutty fishy green boiled shrimp

Appearance

Colorless to light yellow Liquid

Odor Type

fishy

biological source

synthetic

JECFA Number

1035

BRN 

105694

LogP

2.09

CAS DataBase Reference

3581-91-7(CAS DataBase Reference)

NIST Chemistry Reference

Thiazole, 4,5-dimethyl-(3581-91-7)

Safety Information

Hazard Codes 

Xn,Xi,F

Risk Statements 

10-22-37/38-41-36/37/38

Safety Statements 

16-26-39-37/39-36/37/39

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

XJ4380000

HazardClass 

3

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:4,5-Dimethylthiazole
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4,5-Dimethylthiazole Usage And Synthesis

Chemical Properties

4,5-Dimethylthiazole is a colorless to light yellow liquid that has a roasted nutty, meaty, boiled poultry-like odor.

Occurrence

Reported found in peanuts, toasted oats, malt, peach, pork, coffee, krill, shrimp and scallops

Uses

4,5-Dimethylthiazole was used in the preparation of 4-(bromomethyl)-5-(dibromomethyl)thiazole.

Preparation

From methyl-α-bromoethyl ketone; by oxidation of 2-mercaptothiazoles with hydrogen peroxide in aqueous solution; from 2-mercapto-4,5-dimethylthiazole.

Definition

ChEBI: 4,5-Dimethylthiazole is a member of thiazoles.

Aroma threshold values

Detection: 470 ppb

Taste threshold values

Taste characteristics at 5 ppm: fishy, amine and pyridine-like with shrimp and savory nuances

Synthesis Reference(s)

The Journal of Organic Chemistry, 6, p. 764, 1941 DOI: 10.1021/jo01205a011

General Description

4,5-Dimethylthiazole is a thiazoles compounds that containing a thiazole ring substituted at positions 4 and 5 only. Radical bromination of 4,5-dimethylthiazole using N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile yields mono-, tri- and tetrabromo compounds.

4,5-Dimethylthiazole(3581-91-7)Related Product Information

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