4,5-Dimethylthiazole Chemical Properties

Melting point:

83-84 C

Boiling point:

158 °C/742 mmHg (lit.)

Density 

1.07 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.521(lit.)

FEMA 

3274 | 4,5-DIMETHYLTHIAZOLE

Flash point:

124 °F

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

pK1:3.73 (25°C,μ=0.1)

Specific Gravity

1.070

Odor

at 0.10 % in dipropylene glycol. roasted nutty fishy green boiled shrimp

Odor Type

fishy

JECFA Number

1035

BRN 

105694

LogP

2.09

CAS DataBase Reference

3581-91-7(CAS DataBase Reference)

NIST Chemistry Reference

Thiazole, 4,5-dimethyl-(3581-91-7)

Safety Information

Hazard Codes 

Xn,Xi,F

Risk Statements 

10-22-37/38-41-36/37/38

Safety Statements 

16-26-39-37/39-36/37/39

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

XJ4380000

HazardClass 

3

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:4,5-Dimethylthiazole
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4,5-Dimethylthiazole Usage And Synthesis

Chemical Properties

4,5-Dimethylthiazole is a colorless to light yellow liquid that has a roasted nutty, meaty, boiled poultry-like odor.

Occurrence

Reported found in peanuts, toasted oats, malt, peach, pork, coffee, krill, shrimp and scallops

Uses

4,5-Dimethylthiazole was used in the preparation of 4-(bromomethyl)-5-(dibromomethyl)thiazole.

Preparation

From methyl-α-bromoethyl ketone; by oxidation of 2-mercaptothiazoles with hydrogen peroxide in aqueous solution; from 2-mercapto-4,5-dimethylthiazole.

Definition

ChEBI: 4,5-Dimethylthiazole is a member of thiazoles.

Aroma threshold values

Detection: 470 ppb

Taste threshold values

Taste characteristics at 5 ppm: fishy, amine and pyridine-like with shrimp and savory nuances

Synthesis Reference(s)

The Journal of Organic Chemistry, 6, p. 764, 1941 DOI: 10.1021/jo01205a011

General Description

4,5-Dimethylthiazole is a thiazoles compounds that containing a thiazole ring substituted at positions 4 and 5 only. Radical bromination of 4,5-dimethylthiazole using N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile yields mono-, tri- and tetrabromo compounds.

4,5-Dimethylthiazole(3581-91-7)Related Product Information

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• 2-AMINO-4,5-DIMETHYLTHIAZOLE HCL,2-AMINO-4,5-DIMETHYLTHIAZOLE HYDROCHLORIDE