5(R)-HETE
5(R)-HETE Basic information
- Product Name:
- 5(R)-HETE
- Synonyms:
-
- 5(R)-HETE
- 5R-HYDROXY-6E,8Z,11Z,14Z-EICOSATETRAENOIC ACID
- (-)-5(R)-HYDROXY-(6E,8Z,11Z,14Z)-*EICOSA TETRAENOIC
- KGIJOOYOSFUGPC-CABOLEKPSA-N
- 6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (5R,6E,8Z,11Z,14Z)-
- 5(R) HETE,5(R)HETE
- 5(R)-hydroxy-6(E),8(Z),11(Z),14(Z)-ETA
- CAS:
- 61641-47-2
- MF:
- C20H32O3
- MW:
- 320.47
- Mol File:
- 61641-47-2.mol
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5(R)-HETE Chemical Properties
- Boiling point:
- 487.7±45.0 °C(Predicted)
- Density
- 0.984±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
- pka
- 4.67±0.10(Predicted)
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5(R)-HETE Usage And Synthesis
Uses
5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes[1].
Definition
ChEBI: 5R-HETE is a hydroxy fatty acid and a polyunsaturated fatty acid.
References
[1] D B Bittleman, et al. 5-Hydroxyeicosatetraenoic acid (HETE)-induced neutrophil transcellular migration is dependent upon enantiomeric structure. Am J Respir Cell Mol Biol. 1995 Mar;12(3):260-7. DOI:10.1165/ajrcmb.12.3.7873191
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