Basic information Safety Supplier Related

NEUROPEPTIDE Y (13-36), HUMAN, RAT

Basic information Safety Supplier Related

NEUROPEPTIDE Y (13-36), HUMAN, RAT Basic information

Product Name:
NEUROPEPTIDE Y (13-36), HUMAN, RAT
Synonyms:
  • L-Pro-L-Ala-L-Glu-L-Asp-L-Met-L-Ala-L-Arg-L-Tyr-L-Tyr-L-Ser-L-Ala-L-Leu-L-Arg-L-His-L-Tyr-L-Ile-L-Asp(NH2)-L-Leu-L-Ile-L-Thr-L-Arg-L-Gln-L-Arg-L-Tyr-NH2
  • Neuropeptide Y(13-36)【rat】
  • TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2: YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-NH2
  • REF DUPL: H-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
  • H-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2
  • NPY (13-36) (HUMAN, RAT)
  • NEUROPEPTIDE Y (13-36) HUMAN
  • NEUROPEPTIDE Y (13-36), HUMAN, RAT
CAS:
122341-40-6
MF:
C134H207N41O36S
MW:
3000.4
Product Categories:
  • Peptide
Mol File:
122341-40-6.mol
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NEUROPEPTIDE Y (13-36), HUMAN, RAT Chemical Properties

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
Sequence
Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
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NEUROPEPTIDE Y (13-36), HUMAN, RAT Usage And Synthesis

Uses

Neuropeptide Y (13-36), amide, human is a selective?neuropeptide Y2 receptor?agonist[1].

in vivo

Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat[1].Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into na?ve mice impairs social novelty preference, but not sociability, and this effect is inhibited by the NPY Y2 receptor antagonist BIIE 0246[2].

Animal Model:Male ICR mice (age 4-7 weeks)[2]
Dosage:50 ng/mouse
Administration:Intracerebroventricular injection
Result:Significantly decreased interaction time with the new stranger mouse in session 3 that NPY 13-36.

IC 50

NPY Y2 receptor

References

[1] Aguirre JA, et al. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett. 1990 Oct 2;118(1):5-8. DOI:10.1016/0304-3940(90)90235-2
[2] Daiki Ueda, et al. Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice. Br J Pharmacol. 2021 Feb;178(3):726-740. DOI:10.1111/bph.15326

NEUROPEPTIDE Y (13-36), HUMAN, RATSupplier

GL Biochem (Shanghai) Ltd
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Shanghai Hanhong Scientific Co.,Ltd.
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Cellmano Biotech Limited
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NEUROPEPTIDE Y (13-36), HUMAN, RAT(122341-40-6)Related Product Information