Basic information Safety Supplier Related

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH

Basic information Safety Supplier Related

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Basic information

Product Name:
H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH
Synonyms:
  • Neuropeptide W-23(human),WYKHVASPRYHTVGRAAGL MGL,NPW-23, >95%
  • H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH
  • NPW-23 (HUMAN)
  • NEUROPEPTIDE W-23 (HUMAN)
  • TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU
  • Neuropeptide W-23 (huMan) NPW-23 (huMan)
  • L-Leucine, L-tryptophyl-L-tyrosyl-L-lysyl-L-histidyl-L-valyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-tyrosyl-L-histidyl-L-threonyl-L-valylglycyl-L-arginyl-L-alanyl-L-alanylglycyl-L-leucyl-L-leucyl-L-methionylglycyl-
  • Neuropeptide W23(human),hypetension,anorexigenic effect,Neuropeptide W 23(human),Neuropeptide W-23 (human),NPW 23,GPR7,Inhibitor,Neuropeptide W,GPR8,NPBW1,NPBW2,inhibit,NPW23
CAS:
383415-79-0
MF:
C119H183N35O28S
MW:
2584.01
Product Categories:
  • Various peptides
Mol File:
383415-79-0.mol
More
Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Chemical Properties

storage temp. 
Desiccate at -20°C
form 
Solid
color 
White to off-white
Water Solubility 
Soluble to 1 mg/ml in sterile water
More
Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH Usage And Synthesis

Uses

Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8)[1].

in vivo

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats[3].

Animal Model:Male Harlan Sprague-Dawley rats, 250–300 g[2]
Dosage:0.3, 1.0 and 3.0 nM
Administration:Intracerebroventricular injection, 2 μL
Result:Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model:Male Wistar rats weighing 250–300 g[3]
Dosage:2, 4, 6 and 8 nM
Administration:Intra-cerebroventricular injection, 10 μL
Result:Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.

References

[1] Ji L, et al. Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7. J Hypertens. 2015 Dec;33(12):2431-42. DOI:10.1097/HJH.0000000000000723
[2] Pate AT, et al. Neuropeptide W increases mean arterial pressure as a result of behavioral arousal. Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R804-10. DOI:10.1152/ajpregu.00119.2013
[3] Naso T, et al. Central neuropeptide W has anorexigenic effect in rats. J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):228-34. DOI:10.1111/jpn.12067

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OHSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Email
info@cellmano.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
More
Less

H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH(383415-79-0)Related Product Information