4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties

Boiling point:

312.4±35.0 °C(Predicted)

Density 

1.052±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

-2.23±0.40(Predicted)

InChI

InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3

InChIKey

HNVBBNZWMSTMAZ-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1 / PGIII

HazardClass 

IRRITANT

HS Code 

2933399990

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Usage And Synthesis

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester(206989-61-9)Related Product Information

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