(-)-4-BROMOTETRAMISOLE OXALATE Chemical Properties

Melting point:

192 °C (dec.) (lit.)

Flash point:

87℃

storage temp. 

2-8°C

solubility 

Soluble in Water (up to 10 mg/ml)

form 

liquid

color 

White

optical activity

[α]25/D 104°, c = 0.5 in H2O

BRN 

4944883

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-36/37/38-20/21/22

Safety Statements 

24/25-36/37/39-26

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

(-)-4-BROMOTETRAMISOLE OXALATE Usage And Synthesis

Description

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (K_is =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.

Chemical Properties

white to light yellow crystal powde

Uses

L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.

Biochem/physiol Actions

(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.

target

alkaline phosphatase

References

1) Kovach?et al. (1992),?Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst.,?84?515 2) Luo et al. (2000),?Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole;?Am. J. Physiol. Cell Physiol.,?279?C108 3) Scher?et al.?(1998),?The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol.,?12?987

(-)-4-BROMOTETRAMISOLE OXALATE(62284-79-1)Related Product Information

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