EXO1 Chemical Properties

Melting point:

132-134℃

Boiling point:

415.2±45.0 °C(Predicted)

Density 

1.246±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMSO: 19 mg/mL, soluble

form 

solid

pka

-1.09±0.10(Predicted)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

EXO1 Usage And Synthesis

Uses

Exo1 is used in the synthetic preparation of tricyclic heterocyclic compounds as antagonists of tachykinin receptor (substance P receptor) for prevention and/or treatment of substance P-related diseases.

Definition

ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides.

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC 50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (1,6,7,8,9,11ab,12,13,14,14aa-Decahydro-1b,13a-dihydroxy-6b-methyl-4H-cyclopent(f)oxacyclotridecin-4-one ).

EXO1(461681-88-9)Related Product Information

• 4-Fluorobenzylamine
• 4-Fluorobenzamide
• Methyl 2-(methylamino)benzoate
• EXO1
• N-METHYLANTHRANILIC ACID
• METHYL 2-ACETAMIDOBENZOATE
• (4-FLUORO-BENZYL)-METHYL-AMINE
• N-Acetylanthranilic acid
• 4-FLUORO-N-METHYLBENZAMIDE
• exo-1,7,7-trimethylbicyclo(2.2.1)hept-2
• 3-epoxy-exo-norborna
• 1,7,7-trimethyl-,propanoate,exo-bicyclo[2.2.1]heptan-2-
• exo-enterotoxi
• exo-7-oxabicyclo(2.2.1)heptane-3-dicarboxylicanhydrid
• ,endo,exo
• 1,7,7-trimethyl-exo-Bicyclo[2.2.1]heptan-2-o
• 1,2,3,4,10,10-Hexachloro-6,7-Epoxy-1,4,4a,5,6,7,8,8a-octahydro-exo-1,4-exo-5,8-dimethanonaphthalene
• 7,7-trimethylbicyclo[2.2.1]hept-2-yl)oxy]-2-[(exo-ethan