O-ALLYLHYDROXYLAMINE HYDROCHLORIDE Chemical Properties

Melting point:

~170 °C (dec.)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

color 

White to Almost white

BRN 

3552394

InChIKey

XIQUJVRFXPBMHS-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-9

HS Code 

2928009090

MSDS

• Language:English Provider:SigmaAldrich

O-ALLYLHYDROXYLAMINE HYDROCHLORIDE Usage And Synthesis

Preparation

To a solution of 86.8 gm (1.55 moles) of potassium hydroxide in 330 ml of absolute ethanol is added a solution of 159 gm (1.52 moles) of ethyl N-hydroxycarbamate in 330 ml of absolute ethanol. With external cooling to maintain an internal temperature of 25°C to this mixture is added 195.5 gm (1.62 moles) of allyl bromide. After the addition has been com­pleted, the mixture is heated under reflux for 2 hr. After separating the potassium bromide formed during the reaction and washing it with abso­lute alcohol, the alcoholic solution is evaporated under reduced pressure. The residue is dissolved in ether and then the ether solution is extracted repeatedly with 10% aqueous sodium hydroxide solution. [From the ether solution, on evaporation 25.5 gm (18%) of ethyl N,O-diallylhydroxycar-bamate, b.p. 91-92°C (8.55 mm Hg) may be isolated.] The aqueous ex­tract is acidified with 10% aqueous sulfuric acid and the ethyl O-allylhy-droxycarbamate is extracted with ether. Upon evaporating the ether off, 134.2 gm (61%) of the intermediate product, b.p. 107°C (12.5 mm Hg), is isolated.
In a steam distillation apparatus, 134 gm of ethyl O-allylhydroxy-carbamate is treated with a solution of 120 gm of potassium hydroxide in 280 ml of water. The product is steam-distilled into a receiver containing dilute hydrochloric acid.
The steam distillate is evaporated under reduced pressure. The residue is taken up twice in absolute ethanol and dried by evaporation under re­duced pressure. The yield is 91 gm (55%, overall), m.p. 169-170°C. Upon recrystallization from absolute alcohol and dry ether, the melting point is raised to 170.6-170.8°C (172-174°C). Free O-allylhydrox-ylamine has the following reported properties: b.p. 98-99°C, n²⁵_D 1.4300.
The problems connected with the preparation of O-arylhydroxylamines by this method have been attributed to the instability of the aryl- substituted aminooxy group to the hydrolytic system used in its prepara­tion. This problem has recently been circumvented by substituting for ethyl N-hydroxycarbamate, t-butyl N-hydroxycarbamate.

O-ALLYLHYDROXYLAMINE HYDROCHLORIDE(38945-21-0)Related Product Information

• O-ALLYLHYDROXYLAMINE HYDROCHLORIDE
• Hydroxylamine hydrochloride
• 1-(3-([(4-CHLOROPHENYL)SULFONYL]METHYL)-4-NITROPHENYL)-1-ETHANONE O-(3-CHLORO-2-PROPENYL)OXIME
• 1-CHLORO-4-([(CINNAMOYLOXY)IMINO]METHYL)BENZENE
• 5-NITRO-2-([(2,3,3-TRICHLOROALLANOYL)OXY]ETHANIMIDOYL)-1-BENZOFURAN
• 2,4-DICHLORO-1-(([(2,3,3-TRICHLOROALLANOYL)OXY]IMINO)METHYL)BENZENE
• O1-(2,3,3-TRICHLOROACRYLOYL)-3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]PROP-2-ENEHYDROXIMAMIDE
• 4-[(4-CHLOROANILINO)METHYLENE]-3-PHENYL-5(4H)-ISOXAZOLONE
• O1-[3-(5-CHLORO-1,3-DIMETHYL-1H-PYRAZOL-4-YL)ACRYLOYL]-4-CHLOROBENZENE-1-CARBOHYDROXIMAMIDE
• O-ALLYLHYDROXYLAMINE HYDROCHLORIDE HYDRATE
• SPECS AH-262/36795050
• O4-(2,3,3-TRICHLOROACRYLOYL)-2,6-DICHLOROPYRIDINE-4-CARBOHYDROXIMAMIDE
• O1-[3-(5-CHLORO-1,3-DIMETHYL-1H-PYRAZOL-4-YL)ACRYLOYL]-4-(TERT-BUTYL)BENZENE-1-CARBOHYDROXIMAMIDE
• 4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-(3-[4-(DIMETHYLAMINO)PHENYL]-2-PROPENYLIDENE)-5-OXO-2,5-DIHYDROISOXAZOL-2-IUM-3-OLATE
• BUTTPARK 1\01-100
• 4-(PHENYLSULFONYL)-2-BUTANONE O-(3-CHLORO-2-PROPENYL)OXIME
• N-[BIS(4-FLUOROPHENYL)METHYLENE]-N-[(2,3,3-TRICHLOROALLANOYL)OXY]AMINE
• 6-(2-([(3-CHLORO-2-PROPENYL)OXY]IMINO)ETHYL)-1-(3,4-DIMETHOXYPHENETHYL)-4-OXO-1,4-DIHYDRO-5-PYRIMIDINECARBONITRILE