CIS-ACONITIC ANHYDRIDE Chemical Properties

Melting point:

75-78 °C (lit.)

Boiling point:

397.8±25.0 °C(Predicted)

Density 

1.621±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

3?+-.0.10(Predicted)

Sensitive 

Moisture Sensitive

BRN 

127575

CAS DataBase Reference

6318-55-4(CAS DataBase Reference)

EPA Substance Registry System

3-Furanacetic acid, 2,5-dihydro-2,5-dioxo- (6318-55-4)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

2917198090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

CIS-ACONITIC ANHYDRIDE Usage And Synthesis

Uses

cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).

Purification Methods

Reflux it in xylene (7.5 parts) for 1hour, then evaporate and recrystallise the residue from *C6H6. Alternatively, reflux it in Ac2O, evaporate and recrystallise from *C6H6. It is sensitive to moisture. [IR: Groth & Dahlén Acta Chem Scand 21 291 1967, Malachowski & Maslowski Chem Ber 61 2523 1928, NMR: Gawron & Mahajan Biochemistry 5 2335 1966.] [Beilstein 18/8 V 530.]

CIS-ACONITIC ANHYDRIDE(6318-55-4)Related Product Information

• (E)-Ethylidenesuccinic acid
• 3-Methyl-2-buten-1-ol
• 3,3-Dimethylacrylic acid
• 3-METHYL-2(5H)-FURANONE
• VINYLACETIC ACID
• METHYL CROTONATE
• CIS-BUTENEDIOIC ANHYDRIDE
• 2(5H)-Furanone
• 3-PENTENOIC ACID
• MONO-METHYL SUCCINATE
• 3-METHYL-3-BUTEN-1-OL
• ANGELIC ACID
• TRANS-2-PENTEN-1-OL
• TRANS-2-PENTENOIC ACID
• Methyl 4-oxobutanoate
• METHYL 2-PENTENOATE
• CIS-ACONITIC ANHYDRIDE
• Pent-2-ene-1,5-dioic acid
• Aconitic Anhydride