C-JUN N-TERMINAL KINASE Chemical Properties

storage temp. 

−70°C

form 

buffered aqueous glycerol solution

biological source

mouse

Safety Information

Safety Statements 

23-24/25

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

C-JUN N-TERMINAL KINASE Usage And Synthesis

Uses

JNK-3 is an inhibitor of JNK kinase which may be used in the treatment of many hyperactive JNK signaling diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

General Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq)

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