PYRILAMINE Chemical Properties

Melting point:

131-132 °C

Boiling point:

bp5 201°; bp0.06 168-172°

Density 

1.0141 (rough estimate)

refractive index 

nD25 1.5760-1.5765

pka

pKa 4.02(H2O t=25 c=0.002 to 0.01) (Uncertain);8.92 (Uncertain)

Water Solubility 

3.425g/L(37.5 ºC)

EPA Substance Registry System

Mepyramine (91-84-9)

Safety Information

Hazardous Substances Data

91-84-9(Hazardous Substances Data)

Toxicity

LD50 orally in mice: 312 mg/kg (Schlichtergroll)

PYRILAMINE Usage And Synthesis

Uses

Antihistaminic.

Uses

Pyrilamine is also used for allergy symptoms and rhinitis.

Uses

N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine also known as pyrilamine works in synergism with diclofenac as a therapeutic alternative for clinical management of inflammatory pain.

Definition

ChEBI: An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037

General Description

Viscous brown liquid.

Air & Water Reactions

May be sensitive to light. Insoluble in water.

Reactivity Profile

PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.

Fire Hazard

Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.

PYRILAMINE(91-84-9)Related Product Information

• Pyrilamine/Brompheniramine
• Pyrilamine(Mepyramine)Maleate
• pyrilamine N-oxide
• Pyrilamine base/maleate
• N'-(4-CYANOBUTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE
• PYRILAMINE MALEATE,PYRILAMINE MALEATE SALT,PYRILAMINE MALEATE USP/NF,PYRILAMINE MALEATE METHANOL SOLUTION
• N-(4-methoxybenzyl-N',N'-dimethyl-N-2-pyridylethylenediamine monohydrochloride
• PYRILAMINE, [PYRIDINYL 5-3H]-,[PYRIDINYL-5-3H]PYRILAMINE
• PYRILAMINE TANNATE
• PYRILAMINE
• N'-(5-AMINOPENTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE, DIMALEATE SALT