2-Phenoxyethyl chloride Chemical Properties

Melting point:

28°C

Boiling point:

97-98 °C15 mm Hg(lit.)

Density 

1.129 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.534(lit.)

Flash point:

213 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform, Ethyl Acetate

form 

Solid

color 

Pale Yellow Oil to Low Melting Colorless

BRN 

971048

CAS DataBase Reference

622-86-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, (2-chloroethoxy)-(622-86-6)

EPA Substance Registry System

(2-Chloroethoxy)benzene (622-86-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 3265

WGK Germany 

3

F 

10-21

TSCA 

Yes

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Phenoxyethyl chloride Usage And Synthesis

Chemical Properties

Pale Yellow Oil

Uses

Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.

Uses

(2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives.

Synthesis

At room temperature, 2.5 mL of N-methylpyrrolidone (NMP), 1.38 g (10 mmol) of 2-phenoxyethanol and 1.5 mL (11 mmol) of benzenesulfonyl chloride were added to the reaction flask. The mixture was stirred well and then the reaction was continuously stirred at 100 °C for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently extracted by adding 30 mL of dichloromethane and 30 mL of water. The organic layer was separated and washed with saturated brine and dried over anhydrous sodium sulfate. Dichloromethane was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography to give 1.52 g of 2-chlorophenetole in colorless liquid form in 96.8% yield.

References

[1] Patent: CN106187674, 2016, A. Location in patent: Paragraph 0017; 0018
[2] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0232; 0233
[3] Patent: US5527816, 1996, A
[4] Chemical Research in Toxicology, 2000, vol. 13, # 1, p. 53 - 62
[5] Patent: CN106146450, 2016, A. Location in patent: Paragraph 0132; 0133; 0134

2-Phenoxyethyl chloride(622-86-6)Related Product Information

• 1,2,4-Trichlorobenzene
• Phenethyl chloride
• tert-Butylchlorodiphenylsilane
• Dimethyl ether
• 2-Butoxyethanol
• DIETHYLALUMINUM CHLORIDE
• Triton X-100
• Choline chloride
• Ethylbenzene
• Ferric chloride
• Sulfuryl chloride
• 2-Ethoxyethanol
• Chlorphenamine maleate
• Sodium chloride
• Amlodipine Besylate
• Phenetole
• Benzene
• Potassium chloride