4-(Trifluoromethyl)phenacyl bromide Chemical Properties

Melting point:

45 °C

Boiling point:

264.2±40.0 °C(Predicted)

Density 

1.592±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Yellow to Orange

CAS DataBase Reference

383-53-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-36

RIDADR 

1759

WGK Germany 

3

HazardClass 

CORROSIVE

PackingGroup 

III

HS Code 

29147000

4-(Trifluoromethyl)phenacyl bromide Usage And Synthesis

Chemical Properties

White powder or crystal

Synthesis

General procedure for the synthesis of 2-bromo-4'-(trifluoromethyl)acetophenone using 1-(bromoethynyl)-4-(trifluoromethyl)benzene as starting material: a mixed solution of haloalkynes (0.5 mmol), silver fluoride (5 mol%), and water (1 eq.) in trifluoroacetic acid (1 mL) was stirred for 6 hours at 40 °C. Upon completion of the reaction, the trifluoroacetic acid was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-(trifluoromethyl)acetophenone.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121
[3] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822
[4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
[5] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254

4-(Trifluoromethyl)phenacyl bromide(383-53-9)Related Product Information

• 4'-(Trifluoromethyl)acetophenone
• 2-FLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE
• 2-BROMO-2',6'-DICHLORO-4'-(TRIFLUOROMETHYL)-ACETOPHENONE
• 4-(Trifluoromethyl)phenacyl bromide
• 2,3-DIFLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE
• 2,4-BIS(TRIFLUOROMETHYL)PHENACYL BROMIDE
• ETHYL 2-BROMO-3-(4-TRIFLUOROMETHYLPHENYL)-3-OXO-PROPANOATE
• 3-FLUORO-4-(TRIFLUOROMETHYL)PHENACYL BROMIDE
• 2-BROMO-1-(4-TRIFLUOROMETHYL-PHENYL)-PENTAN-1-ONE