Otelixizumab
Otelixizumab Basic information
- Product Name:
- Otelixizumab
- Synonyms:
-
- Otelixizumab
- Research Grade Otelixizumab(DHC27702)
- Otelixizumab (anti-CD3)
- Research Grade Otelixizumab
- CAS:
- 881191-44-2
- MW:
- 0
- Mol File:
- Mol File
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Otelixizumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Otelixizumab Usage And Synthesis
Uses
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].
in vivo
Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice[1].
| Animal Model: | BALB/c-huCD3e mice carrying the human CD3e chain[1] |
| Dosage: | 100 μg/mouse |
| Administration: | Intravenous injection, once |
| Result: | Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells. |
References
[1] Kuhn C, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med. 2011 Feb 2;3(68):68ra10. DOI:10.1126/scitranslmed.3001830
[2] Guglielmi C, et al. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus. Expert Opin Biol Ther. 2016 Jun;16(6):841-6. DOI:10.1080/14712598.2016.1180363
OtelixizumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com