Telisotuzumab
Telisotuzumab Basic information
- Product Name:
- Telisotuzumab
- Synonyms:
-
- Telisotuzumab
- Research Grade Telisotuzumab(DHC34203)
- ABT-700|||Mab-224G11
- Research Grade Telisotuzumab
- Telisotuzumab (anti-HGFR)
- CAS:
- 1781223-80-0
- MW:
- 0
- Mol File:
- Mol File
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Telisotuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Telisotuzumab Usage And Synthesis
Uses
Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocyte growth factor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity[1].
in vivo
Telisotuzumab (ABT-700) (i.p., 2.5-40 mg/kg, twice a week, 90 days) effectively antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in SCID mice with Hs746T cells[1].
| Animal Model: | SCID mice with Hs746T cells[1] |
| Dosage: | 2.5-40 mg/kg |
| Administration: | i.p., twice a week, 90 days |
| Result: | Reduced total and phosphorylated c-Met as well as phosphorylated Akt and Erk. Complete tumor regression at doses above 10 mg/kg but no effective inhibition of tumor growth at doses below 5mg/kg. |
References
[1] Jieyi Wang, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016 Feb 16;16:105. DOI:10.1186/s12885-016-2138-z
TelisotuzumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com