broxaldine Chemical Properties

Boiling point:

538.1±50.0 °C(Predicted)

Density 

1.692±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 1 mg/ml

form 

A solid

pka

0.73±0.50(Predicted)

color 

White to off-white

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

broxaldine Usage And Synthesis

Uses

Broxaldine (Brobenzoxaldine) is an antiprotozoal agent. Broxaldine inhibits Clostridium difficile with a MIC value of 4 μM, and has antifungal effects[1][2].

References

[1] Hazra SK, et al. Therapeutic trial of a combination of broxyquinoline and brobenzoxaldine in the treatment of leprosy. Lepr India. 1979 Oct;51(4):505-10. PMID:118304
[2] AbdelKhalek A, et al. Screening for potent and selective anticlostridial leads among FDA-approved drugs. J Antibiot (Tokyo). 2020 Mar 4. DOI:10.1038/s41429-020-0288-3

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