7-Bromoquinolin-8-ol Chemical Properties

Melting point:

138-143 °C

Boiling point:

327.9±22.0 °C(Predicted)

Density 

1.705±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

2.43±0.50(Predicted)

form 

powder

InChI

InChI=1S/C9H6BrNO/c10-7-4-3-6-2-1-5-11-8(6)9(7)12/h1-5,12H

InChIKey

ICKPMTNGWVNOGC-UHFFFAOYSA-N

SMILES

N1C2C(=CC=C(Br)C=2O)C=CC=1

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26

WGK Germany 

1

7-Bromoquinolin-8-ol Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5,7-dibromo-8-hydroxyquinoline and 7-bromo-8-hydroxyquinoline from 8-hydroxyquinoline was as follows: bromination was carried out according to the method described in the literature [19]. This was done as follows: 8-hydroxyquinoline (2 mmol, 1 eq.) was dissolved in distilled CHCl3 (15 mL) at room temperature and protected from light, followed by the slow addition of different equivalents of molecular bromine (dissolved in CHCl3) over a period of 10 min. The reaction mixture was stirred continuously for 2 days, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the organic layer was washed with 5% NaHCO3 solution (3 x 20 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. Finally, the target product was separated by alumina column chromatography with ethyl acetate/hexane (1:5, 150 mL) as eluent.

References

[1] Letters in Drug Design and Discovery, 2017, vol. 14, # 12, p. 1415 - 1424

7-Bromoquinolin-8-ol(13019-32-4)Related Product Information

• Iodoform
• Fluoranthene
• OXINE-COPPER
• [(5,7-dibromoquinolin-8-yl)oxy]acetic acid
• 2-[(5,7-dibromoquinolin-8-yl)oxy]propanoic acid
• 3-[(5,7-dibromoquinolin-8-yl)oxy]propanoic acid
• broxaldine
• 5-chloro-7-bromo-8-quinolyl vinyl carbonate
• broquinaldol
• 7-bromo-5-methyl-8-quinolyl furoate
• 5,7-DIBROMO-8-HYDROXYQUINOLINE
• (2R,3R,4S,5R)-2-(ACETOXYMETHYL)-6-(5,7-DIBROMOQUINOLIN-8-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIYL TRIACETATE
• 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE
• 7-Bromoquinolin-8-ol