glisoxepide Chemical Properties

Melting point:

189°

Density 

1.2348 (rough estimate)

refractive index 

1.6460 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)

form 

Solid

pka

5.92±0.10(Predicted)

color 

Pale Yellow to Yellow

Safety Information

Toxicity

LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn)

glisoxepide Usage And Synthesis

Originator

Pro-Diaban,Bayer,W. Germany,1974

Uses

Labelled Glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.

Definition

ChEBI: Glisoxepide is a sulfonamide.

Manufacturing Process

There is obtained from 4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]- benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid chloride and 4-(β-aminoethyl)benzene-sulfonamide hydrochloride, MP 213° to 214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the compound N-[[-4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]]-benzenesulfonyl]]-methyl-urethane in the form of colorless crystals of MP 173°C.
From the sulfonyl-urethane described above and N-amino-hexamethyleneimine, there is obtained, in a yield of 70%. the compound 4-[[4-[β-[5-methylisoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonyl]]-1,1-hexamethylenesemicarbazide in the form of colorless crystals of MP 189°C.

Therapeutic Function

Oral hypoglycemic

glisoxepide (25046-79-1)Related Product Information

• Rebamipide
• glisoxepide
• N-(P-SULFAMOYLPHENETHYL)ACETAMIDE
• N,5-DIMETHYLISOXAZOL-3-YLMETHYLAMINE
• TOLAZAMIDE
• ISOXAZOL-3-YLMETHYL-METHYL-AMINE
• 4-(2-Aminoethyl)benzenesulfonamide
• 1-AMINOHOMOPIPERIDINE