Tenatoprazole sodium
Tenatoprazole sodium Basic information
- Product Name:
- Tenatoprazole sodium
- Synonyms:
-
- Tenatoprazole sodium
- Tenatoprazole sodium salt
- Tentoprazole sodiumQ: What is Tentoprazole sodium Q: What is the CAS Number of Tentoprazole sodium Q: What is the storage condition of Tentoprazole sodium
- 5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-imidazo[4,5-b]pyridine, sodium salt
- CAS:
- 335299-59-7
- MF:
- C16H19N4NaO3S
- MW:
- 370.4
- EINECS:
- 1592732-453-0
- Mol File:
- 335299-59-7.mol
Tenatoprazole sodium Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Tenatoprazole sodium Usage And Synthesis
Uses
Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H+/K+-ATPase with an IC50 of 6.2 μM.
in vivo
Tenatoprazole inhibits basal gastric acid secretion in pylorus-ligated rats in a dose-dependent manner (ED50=4.2 mg/kg p.o.). In gastric fistula rats, tenatoprazole (2.5 and 5 mg/kg i.d.) also inhibits gastric acid secretion stimulated by histamine, carbachol or tetragastrin. Furthermore, tenatoprazole prevents the formation of water-immersion restraint stress-, pylorus ligation- and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcer in rats[1]. Maximum binding of tenatoprazole is 2.9 nmol/mg of the enzyme at 2 h after IV administration. The binding sites of tenatoprazole are in the TM5/6 region at Cys813 and Cys822. The bioavailability of tenatoprazole is two-fold greater in the (S)-tenatoprazole sodium salt hydrate form as compared to the free form in dogs[2].
References
[1] Shin JM, et al. Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo. Biochem Pharmacol. 2006 Mar 14;71(6):837-49. DOI:10.1016/j.bcp.2005.11.030
[2] https://www.ncbi.nlm.nih.gov/pubmed/16405921 DOI:10.1358/mf.1999.21.2.529238
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