Tenatoprazole Chemical Properties

Melting point:

178-180°C

Boiling point:

570.4±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated)

form 

Solid

pka

4.61±0.40(Predicted)

color 

Off-White to Light Pink

Stability:

Hygroscopic, Temperature Sensitive

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37

Tenatoprazole Usage And Synthesis

Description

Tenatoprazole is a proton pump inhibitor, blocking hog gastric H⁺/K⁺-ATPase activity with an IC₅₀ value of 6.2 μM. It is orally bioavailable, blocking induced gastric acid secretion and ulcer formation in rats and humans. Tenatoprazole has a prolonged plasma half-life resulting in persistent effectiveness after withdrawal.

Chemical Properties

White Crystalline Powder

Uses

A proton pump inhibitor for reduction and/or prevention of gastrointestinal disorders.

Definition

ChEBI: 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine is an imidazopyridine.

References

[1] K UCHIYAMA. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats.[J]. Methods and findings in experimental and clinical pharmacology, 1999, 21 2: 115-122. DOI: 10.1358/mf.1999.21.2.529238
[2] J. P. GALMICHE. Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in healthy volunteers[J]. Alimentary Pharmacology & Therapeutics, 2004, 19 6: 655-662. DOI: 10.1111/j.1365-2036.2004.01893.x
[3] RICHARD H HUNT. Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers.[J]. American Journal of Gastroenterology, 2005, 100 9: 1949-1956. DOI: 10.1111/j.1572-0241.2005.41956.x

Tenatoprazole(113712-98-4)Related Product Information

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