GW-6604
GW-6604 Basic information
- Product Name:
- GW-6604
- Synonyms:
-
- GW-6604
- 2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine
- 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine
- GW6604;GW-6604;GW 6604.
- Pyridine, 2-phenyl-4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-
- GW-6604, 10 mM in DMSO
- CAS:
- 452342-37-9
- MF:
- C19H14N4
- MW:
- 298.34
- Mol File:
- 452342-37-9.mol
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GW-6604 Chemical Properties
- Melting point:
- 147 °C(Solv: dichloromethane (75-09-2); pentane (109-66-0))
- Boiling point:
- 505.2±50.0 °C(Predicted)
- Density
- 1.226±0.06 g/cm3(Predicted)
- pka
- 8.80±0.50(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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GW-6604 Usage And Synthesis
Uses
GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].
in vivo
GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks) dependently inhibits hepatic COL IA1 overexpression in an acute DMN model in SD rats, reducing its expression by 80%. Normal liver weight was maintained, liver fibrosis was effectively reduced and matrix degeneration was increased[1].
References
[1] Anne-Charlotte de Gouville, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005 May;145(2):166-77. DOI:10.1038/sj.bjp.0706172
GW-6604Supplier
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
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- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Rechem science Co., Ltd.
- Tel
- 021-31433387 15618786686
- sales@rechemscience.com