SERGLIFLOZIN
SERGLIFLOZIN Basic information
- Product Name:
- SERGLIFLOZIN
- Synonyms:
-
- QLXKHBNJTPICNF-QMCAAQAGSA-N
- SERGLIFLOZIN
- 2-[(4-Methoxyphenyl)methyl]phenyl-beta-D-glucopyranoside-6-(ethyl carbonate)
- Sergliflozin etabonate
- 2-(4-Methoxybenzyl)phenyl6-O-(ethoxycarbonyl)-beta-D-glucopyranoside
- ethyl [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-[(4-methoxyphenyl)methyl]phenoxy]oxan-2-yl]methyl carbonate
- β-D-Glucopyranoside,2-[(4-methoxyphenyl)methyl]phenyl,6-(ethyl carbonate)
- GW869682
- CAS:
- 408504-26-7
- MF:
- C23H28O9
- MW:
- 448.46
- Mol File:
- 408504-26-7.mol
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SERGLIFLOZIN Chemical Properties
- Boiling point:
- 611.5±55.0 °C(Predicted)
- Density
- 1.312
- pka
- 12.74±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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SERGLIFLOZIN Usage And Synthesis
Uses
Treatment of type 2 diabetes.
Definition
ChEBI: Sergliflozin etabonate is a glycoside.
in vivo
Sergliflozin etabonate (1, 3, 10, 30 mg/kg; oral; once) significantly reduces non-fasting blood glucose levels in KK-Ay mice in a dose-dependent manner[1].
Sergliflozin etabonate (1.7, 8.4, 45.7 mg/kg in the 0.001, 0.005, and 0.025% sergliflozin etabonate; fed; daily for 9 weeks) reduces non-fasting blood glucose level and decreases triglyceride content in the liver in a dose-dependent manner in KK-Ay mice[1].
| Animal Model: | 14 weeks, Female KK-Ay mice[1] |
| Dosage: | 1, 3, 10, 30 mg/kg |
| Administration: | Oral; once |
| Result: | Significantly reduced non-fasting blood glucose level with the reduction in blood glucose level at 2 h post dosing in the 1 mg/kg group, 3 mg/kg group, 10 mg/kg group, and 30 mg/kg group was 12, 15, 28, and 39%, respectively. |
| Animal Model: | 4 weeks, Female KK-Ay mice[1] |
| Dosage: | 1.7, 8.4, 45.7 mg/kg in the 0.001, 0.005, and 0.025% sergliflozin etabonate |
| Administration: | Fed, daily for 9 weeks |
| Result: | Reduced non-fasting blood glucose level and decreased triglyceride content in the liver in a dose-dependent manner in diabetic control KK-Ay mice. |
IC 50
SGLT2
SERGLIFLOZINSupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- 021-50182298 021-50180596
- sales@boylechem.com
ZHIWE CHEMTECH CO LTD
- Tel
- 021-20221225 13917446399
- zwchem@163.com
Chembest Research Laboratories Limited
- Tel
- +86-21-20908456
- sales@BioChemBest.com
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
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SERGLIFLOZIN(408504-26-7)Related Product Information
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- Tofogliflozin
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Acetoxy Empagliflozin
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