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Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

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Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Basic information

Product Name:
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
Synonyms:
  • BUTTPARK 46\18-97
  • METHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
  • Methyl2-chloro-4-(trifluoromethyl)pyrimidine-5-
  • 4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]-2-methylbenzoate
  • Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-
  • Methyl 2-Chloro-4-(trif1uoromethyl) pyridine-5-carboxylate
  • Methyl 2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylate
  • 2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester
CAS:
175137-27-6
MF:
C7H4ClF3N2O2
MW:
240.57
Product Categories:
  • Esters
  • Pyrazines, Pyrimidines & Pyridazines
  • Heterocycle
Mol File:
175137-27-6.mol
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Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Chemical Properties

Melting point:
253-254 °C
Boiling point:
76-78°C 0,5mm
Density 
1.491
refractive index 
n20/D1.468
Flash point:
>110℃
storage temp. 
2-8°C
pka
-5.70±0.29(Predicted)
CAS DataBase Reference
175137-27-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22-22
Safety Statements 
26-36/37/39-23-51-24/25-22
RIDADR 
UN 2810 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933599590
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Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Usage And Synthesis

Uses

Methyl 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate is used in the synthetic preparation and discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide (G931520) which is a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.

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