CYCLO(ARG-GLY-ASP-D-PHE-VAL) Chemical Properties

Density 

1.45±0.1 g/cm3(Predicted)

storage temp. 

−20°C

form 

White solid

pka

4.01±0.10(Predicted)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CYCLO(ARG-GLY-ASP-D-PHE-VAL) Usage And Synthesis

General Description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Biochem/physiol Actions

Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates

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