Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) Chemical Properties

Melting point:

210-212 °C (decomp)

storage temp. 

2-8°C

form 

Powder

color 

orange

Sensitive 

air sensitive

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2931.90.6000

Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) Usage And Synthesis

Reaction

Highly active catalyst for hydrogenation of simple ketones giving high enantioselectivity when sterically unsymmetrical ketones such as acetophenone, heteroaryl ketones, benzophenones, cyclopropyl ketones, and cyclohexyl ketones are substrates. Ee's are enhanced with XylBINAP relative to BINAP. The otherwise poorly bonded ketone is held in the transition state by hydrogen bonding to the protic bidentate amine.
Carbonyl groups are selectively reduced even when olefins exist in the same molecule.
In the presence of strong base, and catalyst, simple ketones, having substituents at the α-position, may be induced to undergo dynamic kinectic resolution during their hydrogenation to produce two chiral carbon centers in high yield.

Uses

Catalyst for:

• Preparation of cyclometalated ruthenium 1,1-dianisyl-2-isopropyl-1,2-ethylenediamine complexes via asymmetric hydrogenation of ketones
• Enantioselective hydrogenation of an α-alkoxy substituted ketone with chiral ruthenium (phosphinoferrocenyl)oxazoline complexes
• Nonclassical asymmeteric hydrogen transfer between alcohols and carbonyl compounds
• Asymmetric hydrogenation of amino and heteroaromatic ketones

• Pharmacologically active substituted oxazolidinone used as NPC1L1 ligand for inhibition of cholesterol absorption

Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)(220114-01-2)Related Product Information

• (S)-Daipen
• 2,2-BIS(4-METHOXYLPHENYL)ETHYLAMINE
• (S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL
• Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
• (S)-(-)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl
• DICHLORO[(S)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL][(S)-1,1-BIS(P-METHOXYPHENYL)-2-ISOPROPYLETHANE-1,2-DIAMINE]RUTHENIUM(II)
• (2S,3S)-(-)-2,3-BUTANEDIAMINE DIHYDROCHLORIDE
• DICHLORO[(R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]RUTHENIUM (II)
• (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYLBUTANE
• 2-(4-METHOXYPHENYL)-2-PHENYLETHYLAMINE HYDROCHLORIDE