ISOXATHION Chemical Properties

Melting point:

<25℃

Boiling point:

160°C (rough estimate)

Density 

1.48 g/ml

vapor pressure 

<1.3 x 10^-4 Pa (25 °C)

storage temp. 

0-6°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

Water Solubility 

1.9 mg l^-1 (25 °C)

pka

-6.17±0.28(Predicted)

form 

liquid

color 

Colourless to Pale Yellow

Specific Gravity

1.48

BRN 

1222135

EPA Substance Registry System

Isoxathion (18854-01-8)

Safety Information

Hazard Codes 

T,N

Risk Statements 

24/25-50/53

Safety Statements 

28-36/37-45-60-61

RIDADR 

3018

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29349990

Hazardous Substances Data

18854-01-8(Hazardous Substances Data)

ISOXATHION Usage And Synthesis

Description

Isoxathion is a pale yellow liquid, bp 160 ?C/0.15 mm Hg, vp <0.133mPa (25 ?C). Solubility in water is 1.9 mg/L (25 ?C). It is readily soluble in most organic solvents. Log Kow = 3.88. It is unstable to alkali.

Uses

Isoxathion is used to control sucking pests, leaf miners and some chewing pests in a variety of fruit, vegetables and ornamental plants.

Uses

Isoxathion is used as a pesticide.

Definition

ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group is replaced by a 5-phenyl-1,2-oxazol-3-yl group.

Metabolic pathway

The principal route of isoxathion metabolism in soil, plants and mammals is by hydrolysis, probably via the oxon to 3-hydroxy-5-phenylisoxazole which is rapidly conjugated in both plants and rats. In soils, and to a lesser extent in plants and mammals, further metabolism of 3-hydroxy- 5-phenylisoxazole proceeds via opening of the isoxazole ring to give various metabolites of which benzoic acid is one of the more important. De-ethylation of the phosphate moiety has not been observed.

Metabolism

The principal degradation route of isoxathion in animals, plants, and soil is cleavage of P?O-isoxazole through oxidative desulfuration to the oxon followed by hydrolysis to 3-hydroxy-5-phenylisoxazole, which is conjugated in both plants and rats.

Toxicity evaluation

The acute oral LD₅₀ for rats is 112 mg/kg. NOEL (2 yr) for rats is 1.2 mg/kg b.w. DT₅₀ in soil is 9–40 d.

Degradation

Isoxathion is unstable to alkalis (PM). The hydrolysis product, 3-hydroxy- 5-phenylisoxazole (2), yielded 5-phenyl-3H-oxazolin-2-one (3) as the major photoproduct via a photolytic rearrangement (Nakagawa et al.,1974).

ISOXATHION(18854-01-8)Related Product Information

• Linezolid
• Mifepristone
• Lincomycin
• Nitenpyram
• ISOXATHION OXON,ISOXATHION OXON STANDARD
• Phosphorothioic acid, O-(4-chloro-5-phenyl-3-isoxazolyl) O,O-diethyl e ster
• Methyl isoxathion
• 5-PHENYLISOXAZOLE
• ISOXATHION