forphenicinol Chemical Properties

Boiling point:

334.28°C (rough estimate)

Density 

1.3075 (rough estimate)

refractive index 

1.5270 (estimate)

storage temp. 

-20°C

solubility 

DMSO: soluble,Methanol: soluble,

form 

A solid

Water Solubility 

Water: soluble

forphenicinol Usage And Synthesis

Uses

Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.

References

[1] Ishizuka, et al. Studies on effects of forphenicinol on immune responses. J. Antibiot. (Tokyo) 35(8), 1042-1048 (1982).

forphenicinol(71522-58-2)Related Product Information

• (S)-3-HYDROXYPHENYLGLYCINE
• (RS)-3-HYDROXYPHENYLGLYCINE
• (S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE
• 2-AMINO-2-(4-METHYLPHENYL)ACETIC ACID
• Benzenemethanol, 4-[(1R)-1-aminoethyl]-
• forphenicinol