NQ301 Chemical Properties

Melting point:

241-243 °C(Solv: ethanol (64-17-5))

Boiling point:

476.8±45.0 °C(Predicted)

Density 

1.40±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO:10.0(Max Conc. mg/mL);30.7(Max Conc. mM)

form 

powder

pka

-5.25±0.20(Predicted)

color 

faint red to dark red

InChI

1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3

InChIKey

LSQZKIQSQHZVQS-UHFFFAOYSA-N

SMILES

O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O

Safety Information

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NQ301 Usage And Synthesis

Uses

NQ 301 possess antiplatelet effect, making it an antithrombotic agent. It significantly inhibited the collagen-?, thrombin-?, arachidonic acid-?, thapsigargin- and calcium ionophore A23187-?induced aggregation of washed human platelets.

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.