JNJ-38877605-d1
JNJ-38877605-d1 Basic information
- Product Name:
- JNJ-38877605-d1
- Synonyms:
-
- JNJ-38877605-d1
- Quinoline-2-d, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-
- CAS:
- 1936472-36-4
- MF:
- C19H12DF2N7
- MW:
- 378.36
- Mol File:
- 1936472-36-4.mol
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JNJ-38877605-d1 Chemical Properties
- form
- Solid
- color
- White to off-white
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JNJ-38877605-d1 Usage And Synthesis
Uses
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3[1].
References
[1] Sikkema BJ, et al. Quantification and clinical validation of the selective MET kinase inhibitor DO-2 and its metabolites DO-5 and M3 in human plasma. J Pharm Biomed Anal. 2024 Jan 4;240:115962. DOI:10.1016/j.jpba.2024.115962