4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Basic information
- Product Name:
- 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
- Synonyms:
-
- 1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-
- N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
- 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
- JNJ 17203212
- JNJ-17203212 (JNJ17203212
- management,inhibit,pain,migrainem,Transient receptor potential channels,TRP Channel,JNJ-17203212,JNJ17203212,Inhibitor,JNJ 17203212
- 4-(3-(Trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide
- 4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE
- CAS:
- 821768-06-3
- MF:
- C17H15F6N5O
- MW:
- 419.32
- Mol File:
- 821768-06-3.mol
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4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Chemical Properties
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: >20mg/mL
- form
- Powder
- color
- white to off-white
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4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Usage And Synthesis
Uses
JNJ 17203212 is a high affinity TRPV1 receptor antagonist.
in vivo
JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression[2].
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner[2].
| Animal Model: | Male Sprague-Dawley rats (260-300 g)[2] |
| Dosage: | 0.3 mg/kg |
| Administration: | Intravenous injection |
| Result: | Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS. |
IC 50
TRPV1
storage
Store at +4°C
4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamideSupplier
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