MELK-T1(JNJ-47117096)
MELK-T1(JNJ-47117096) Basic information
- Product Name:
- MELK-T1(JNJ-47117096)
- Synonyms:
-
- MELK-T1(JNJ-47117096)
- MELK-T1
- 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
- JNJ-47117096
- Benzamide, 2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-
- CAS:
- 1610586-62-3
- MF:
- C21H22N4O2
- MW:
- 362.42
- Mol File:
- 1610586-62-3.mol
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MELK-T1(JNJ-47117096) Chemical Properties
- Boiling point:
- 558.8±50.0 °C(Predicted)
- Density
- 1.250±0.06 g/cm3(Predicted)
- pka
- 13.13±0.50(Predicted)
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MELK-T1(JNJ-47117096) Usage And Synthesis
Uses
JNJ-47117096 is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM[1].
References
[1] Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6(1):25-30. DOI:10.1021/ml5001245
[2] Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35(6). pii: e00267. DOI:10.1042/BSR20150194
MELK-T1(JNJ-47117096)Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
Twochem Co.Ltd.
- Tel
- 021-58111628 15800915896
- sales@twochem.com