JNJ-64619178
JNJ-64619178 Basic information
- Product Name:
- JNJ-64619178
- Synonyms:
-
- JNJ-64619178
- JNJ 64619178;JNJ64619178
- CS-2829
- 1,2-Cyclopentanediol, 3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2R,3S,5R)-
- (1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol
- inhibit,JNJ 64619178,Inhibitor,JNJ64619178,Histone Methyltransferase,Onametostat,JNJ-64619178
- (1S,2R,3S,5R)-3-[2-(2-amino-3-bromo-7-quinolinyl)ethyl]-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1,2-cyclopentanediol
- Onametostat (JNJ-64619178)
- CAS:
- 2086772-26-9
- MF:
- C22H23BrN6O2
- MW:
- 483.36
- Mol File:
- 2086772-26-9.mol
JNJ-64619178 Chemical Properties
- Boiling point:
- 636.2±50.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:111.0(Max Conc. mg/mL);229.64(Max Conc. mM)
- form
- A solid
- pka
- 13.37±0.70(Predicted)
- color
- Off-white to light yellow
JNJ-64619178 Usage And Synthesis
Uses
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Onametostat has potent activity in lung cancer[1][2].
in vivo
Oral administration of Onametostat results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer? cancer mouse xenograft models[1].
IC 50
PRMT5
References
[1] Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.
[2] Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388. DOI:10.1248/cpb.c18-00980
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