Basic information Safety Supplier Related

JNJ-10198409

Basic information Safety Supplier Related

JNJ-10198409 Basic information

Product Name:
JNJ-10198409
Synonyms:
  • PDGFR Tyrosine Kinase Inhibitor IV
  • JNJ-10198409 (This product is only available in Japan.)
  • N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
  • JNJ-10198409
  • Indeno[1,2-c]pyrazol-3-amine, N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-
  • RWJ 540973, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine
  • JNJ-10198409, Free Base
  • 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine
CAS:
627518-40-5
MF:
C18H16FN3O2
MW:
325.34
Mol File:
627518-40-5.mol
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JNJ-10198409 Chemical Properties

Melting point:
171-173.5 °C
Boiling point:
528.8±50.0 °C(Predicted)
Density 
1.366±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
14.01±0.20(Predicted)
color 
off-white
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Safety Information

WGK Germany 
3
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JNJ-10198409 Usage And Synthesis

Biological Activity

jnj-10198409 is a small molecule inhibitor of platelet-derived growth factor (pdgf-bb) tyrosine kinase [1].platelet-derived growth factor (pdgf) is a ubiquitous mitogen involved in regulating cell growth and division, embryonic development, cell proliferation, cell migration, and angiogenesis. overexpression of pdgf has been associated with several diseases such as atherosclerosis, fibrotic disorders and malignancies. inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (pdgf-bb) receptor can have potent antiangiogenic and antiproliferative activity. recombinant pdgf is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry to treat bone loss [2].in human coronary artery smooth muscle cells, jnj-10198409 inhibited the activity of platelet-derived growth factor (pdgf-bb) tyrosine kinase with an ic50 value of 4.2 nm when tested. jnj-10198409 was a competitive antagonist of the atp binding and hydrolysis at pdgf-bb receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis [1].

storage

Store at -20°C

References

[1] ho c y, ludovici d w, maharoof u s m, et al. (6, 7-dimethoxy-2, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells[j]. journal of medicinal chemistry, 2005, 48(26): 8163-8173.
[2] raines e w, bowen-pope d f, ross r. platelet-derived growth factor[m]//peptide growth factors and their receptors i. springer berlin heidelberg, 1990: 173-262.

JNJ-10198409Supplier

Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878
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chemcell@hotmail.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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